Family Foundation Model

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Ligase

Enzymes that join two molecules using energy from a triphosphate.

Targets

30

servable in this model

Ligands

93

measured here and in at least one other family

Comparisons

332

involving this family

The data

QuantityValue
Measurements332
Activity range, pActivity3.92 to 10.3
Median activity8.1

Endpoints

EndpointMeasurements
Kd145
IC50105
Ki73
EC509

Comparing two targets inside this family

This family carries 1 held-out comparisons between two of its own targets, below the 200 this site requires before publishing an accuracy, so none is published for it. The tool still answers, and labels the answer with the figure measured across every family, 0.78 on 32,738 comparisons.

17 comparisons between two targets in this family were formed from 12 compounds over 14 proteins, and entered the fit or the holdout.

How far its compounds reach

Every ligand counted here is measured in this family and in at least one other. The question worth asking is how many families a compound reaches altogether, because a compound seen in four families is a very different starting point from one seen in two.

Families a compound reachesCompounds
Two71
Three9
Four or more13

Which families those compounds also reach

FamilyShared compounds
Electrochemical transporter31
Transferase24
Cytochrome P45020
Oxidoreductase18
Kinase13
Voltage-gated ion channel10

Targets in this family

Accession
O00763
O15067
O95573
P12081
P15104
P17812
P18858
P22102
P22314
P26640
P31327
P33121
P41252
P49589
P49916
P49917
P53597
P54136
P54577
Q05932
Q6XQN6
Q8TBC4
Q9HCC0
Q9NRF8
Q9NSD9
Q9NSE4
Q9P2J5
Q9P2R7
Q9UKU0
Q9ULC5