Family Foundation Model

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Family B G protein-coupled receptor

A protein family as ChEMBL classifies it.

Targets

15

servable in this model

Ligands

123

measured here and in at least one other family

Comparisons

390

involving this family

The data

QuantityValue
Measurements390
Activity range, pActivity4.89 to 10.66
Median activity5.64

Endpoints

EndpointMeasurements
IC50290
EC5084
Ki16

Comparing two targets inside this family

This family carries 50 held-out comparisons between two of its own targets, below the 200 this site requires before publishing an accuracy, so none is published for it. The tool still answers, and labels the answer with the figure measured across every family, 0.78 on 32,738 comparisons.

584 comparisons between two targets in this family were formed from 456 compounds over 12 proteins, and entered the fit or the holdout.

How far its compounds reach

Every ligand counted here is measured in this family and in at least one other. The question worth asking is how many families a compound reaches altogether, because a compound seen in four families is a very different starting point from one seen in two.

Families a compound reachesCompounds
Two104
Three14
Four or more5

Which families those compounds also reach

FamilyShared compounds
Kinase53
Family A G protein-coupled receptor48
Cytochrome P45017
Oxidoreductase10
Electrochemical transporter8
Voltage-gated ion channel7

Targets in this family

Accession
O95838
P30988
P32241
P34998
P41587
P43220
P47871
P47872
P48546
P48960
Q02643
Q03431
Q13324
Q16602
Q5T601