The rhodopsin-like receptors, the largest and most drugged receptor class, and the family the sibling GPCR Foundation Model covers on its own.
servable in this model
measured here and in at least one other family
involving this family
| Quantity | Value |
|---|---|
| Measurements | 25,162 |
| Activity range, pActivity | 2.13 to 12.52 |
| Median activity | 6.39 |
| Endpoint | Measurements |
|---|---|
| IC50 | 12,423 |
| Ki | 12,047 |
| EC50 | 641 |
| Kd | 51 |
Every ligand counted here is measured in this family and in at least one other. The question worth asking is how many families a compound reaches altogether, because a compound seen in four families is a very different starting point from one seen in two.
| Families a compound reaches | Compounds |
|---|---|
| Two | 5,062 |
| Three | 494 |
| Four or more | 314 |
| Family | Shared compounds |
|---|---|
| Voltage-gated ion channel | 2,166 |
| Electrochemical transporter | 1,980 |
| Cytochrome P450 | 1,280 |
| Ligand-gated ion channel | 298 |
| Nuclear receptor | 237 |
| Oxidoreductase | 213 |