Family Foundation Model

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Primary active transporter

A protein family as ChEMBL classifies it.

Targets

13

servable in this model

Ligands

615

measured here and in at least one other family

Comparisons

3,907

involving this family

The data

QuantityValue
Measurements3,907
Activity range, pActivity1.85 to 8.82
Median activity4.8

Endpoints

EndpointMeasurements
IC503,566
Ki312
EC5023
Kd6

Comparing two targets inside this family

This family carries 170 held-out comparisons between two of its own targets, below the 200 this site requires before publishing an accuracy, so none is published for it. The tool still answers, and labels the answer with the figure measured across every family, 0.78 on 32,738 comparisons.

1,410 comparisons between two targets in this family were formed from 706 compounds over 14 proteins, and entered the fit or the holdout.

How far its compounds reach

Every ligand counted here is measured in this family and in at least one other. The question worth asking is how many families a compound reaches altogether, because a compound seen in four families is a very different starting point from one seen in two.

Families a compound reachesCompounds
Two300
Three107
Four or more208

Which families those compounds also reach

FamilyShared compounds
Cytochrome P450225
Electrochemical transporter208
Family A G protein-coupled receptor203
Oxidoreductase168
Voltage-gated ion channel127
Kinase124

Targets in this family

Accession
O15438
O15439
O15440
O95342
P00395
P00403
P08183
P21439
P33527
P55072
Q09428
Q92887
Q9UNQ0