A protein family as ChEMBL classifies it.
servable in this model
measured here and in at least one other family
involving this family
| Quantity | Value |
|---|---|
| Measurements | 3,907 |
| Activity range, pActivity | 1.85 to 8.82 |
| Median activity | 4.8 |
| Endpoint | Measurements |
|---|---|
| IC50 | 3,566 |
| Ki | 312 |
| EC50 | 23 |
| Kd | 6 |
Every ligand counted here is measured in this family and in at least one other. The question worth asking is how many families a compound reaches altogether, because a compound seen in four families is a very different starting point from one seen in two.
| Families a compound reaches | Compounds |
|---|---|
| Two | 300 |
| Three | 107 |
| Four or more | 208 |
| Family | Shared compounds |
|---|---|
| Cytochrome P450 | 225 |
| Electrochemical transporter | 208 |
| Family A G protein-coupled receptor | 203 |
| Oxidoreductase | 168 |
| Voltage-gated ion channel | 127 |
| Kinase | 124 |