Family Foundation Model

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Family C G protein-coupled receptor

A protein family as ChEMBL classifies it.

Targets

10

servable in this model

Ligands

135

measured here and in at least one other family

Comparisons

334

involving this family

The data

QuantityValue
Measurements334
Activity range, pActivity2.6 to 11.0
Median activity6.87

Endpoints

EndpointMeasurements
IC50208
Ki64
EC5062

Comparing two targets inside this family

This family carries 85 held-out comparisons between two of its own targets, below the 200 this site requires before publishing an accuracy, so none is published for it. The tool still answers, and labels the answer with the figure measured across every family, 0.78 on 32,738 comparisons.

1,194 comparisons between two targets in this family were formed from 576 compounds over 8 proteins, and entered the fit or the holdout.

How far its compounds reach

Every ligand counted here is measured in this family and in at least one other. The question worth asking is how many families a compound reaches altogether, because a compound seen in four families is a very different starting point from one seen in two.

Families a compound reachesCompounds
Two111
Three11
Four or more13

Which families those compounds also reach

FamilyShared compounds
Cytochrome P45061
Voltage-gated ion channel52
Family A G protein-coupled receptor21
Electrochemical transporter16
Ligand-gated ion channel11
Oxidoreductase10

Targets in this family

Accession
O00222
O15303
P41180
P41594
Q13255
Q14416
Q14831
Q14832
Q14833
Q9UBS5