Family Foundation Model

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Frizzled family G protein-coupled receptor

A protein family as ChEMBL classifies it.

Targets

4

servable in this model

Ligands

37

measured here and in at least one other family

Comparisons

41

involving this family

The data

QuantityValue
Measurements41
Activity range, pActivity5.49 to 9.7
Median activity7.36

Endpoints

EndpointMeasurements
IC5034
Ki6
EC501

Comparing two targets inside this family

This family carries 1 held-out comparisons between two of its own targets, below the 200 this site requires before publishing an accuracy, so none is published for it. The tool still answers, and labels the answer with the figure measured across every family, 0.78 on 32,738 comparisons.

5 comparisons between two targets in this family were formed from 5 compounds over 3 proteins, and entered the fit or the holdout.

How far its compounds reach

Every ligand counted here is measured in this family and in at least one other. The question worth asking is how many families a compound reaches altogether, because a compound seen in four families is a very different starting point from one seen in two.

Families a compound reachesCompounds
Two32
Three4
Four or more1

Which families those compounds also reach

FamilyShared compounds
Kinase21
Voltage-gated ion channel10
Transferase3
Family A G protein-coupled receptor2
Lyase2
Primary active transporter1

Targets in this family

Accession
O75084
Q14332
Q99835
Q9UP38